Correct Answer - C
Ans. is 'c' i.e., Doxacurium
Competitive (nondepolarizing) blockers are of two types -
Benzylisoquinolone derivatives
This includes → d-TC, doxacurium, atracurium, cisatracurium,
mivacurium, metocurine.
These drugs have tendency to release histamine and to block
autonomic ganglion.
Amminio steroid derivatives
This include pancuronium, rocuronium, vecuronium, pipecuronium,
rapacuronium.
These drugs do not block autonomic ganglia and have minimal
histamine releasing property

NEET PG25 Recall available in group
@doctorusmle

Correct Answer - A
Ans. is'a' i.e., Aplastic anemia
Two severe side effects of felbamate are for which FDA has issued
warning that drug not be used are hepatic failure and aplastic
anemia

Correct Answer - B
Ans. B. Ephedrine
[Ref KDT 7th/e p. 70 & 6th/e p. 68; Laurence 50/e p. 448; Katzung
11 `"/e p. 32]
Tachyphylaxis:
* Rapidly diminishing response to repeated administration of a drug.
Tachyphylaxis may occur due to:
* Down-regulation of receptors
- When tissues are continuously exposed to an agonist, the number
of receptors decreases (down-regulation).
- It occurs in asthmatics who use 132-agonist bronchodilators
excessively.
* Depletion of stored neurotransmitter
- It is particularly common with indirectly acting sympathomimetics
drugs, e.g. amphetamine, tyramine and ephedrine.
- It is due to depletion of releasable pool of noradrenaline from
adrenergic nerve terminals.

Correct Answer - A
Ans. is 'a' i.e., Imatinib and sunitinib
Molecular targeted agents
Tyrosine kinase inhibitors
Competitive inhibitors → Imatinib, Nilotinib, Sunitinib, Dasatinib,
Erlotinib, Gefitinib, Lapatinib, Sorafenib (Remember all end with
' nib').
Monoclonal antibodies → Cetuximab, panitumumab.
HER2
/neu (ERB B2
) inhibitors Monoclonal antibody - Trastuzumab.
Targeted antibody → Gemtuzumab (anti CD-33), Rituximab (anti -
CD20), Alemtuzumab (anti CD-52).
Vascular endothelial growth factor (VEGF) inhibitor → Monoclonal
antibody - Bevacizumab.
Proteosome inhibitors → Bortezomib.
Histone deacetylase inhibitor → Vorinostat
DNA - methyltransferase inhibitor → 5-azacytidine, 2-deoxy-5
azacytidine
All - trans-retinoic acid.
Biological response modifier - Recombinant IL-2 (aldesleukin,
denileukin)

Correct Answer - A
Ans: A. Neostigmine
Neostigmine has been traditionally used as the agent of choice
to reverse Neuromuscular Blockade (NMB) after muscle paralysis
during general anesthesia.
Anticholinesterases (neostigmine) are generally used to reverse the
effects of neuromuscular blocking agents

Correct Answer - B
Ans: B. Trihexyphenidyl
* Fluphenazine may block the effects of agents used to treat
Parkinson's disease such as levodopa/carbidopa.
* Trihexyphenidylis an antispasmodic drug that exerts a direct
inhibitory effect on the parasympathetic nervous system.
- It also has a relaxing effect on smooth muscle.
- It is indicated in all forms of Parkinsonism.
* Trihexyphenidyl works as an anticholinergic and is used for the
treatment of tremors, spasms, stiffness, and weak muscle control
seen in patients with Parkinson’s disease.
- It can also be used for the prevention or treatment of similar
muscular conditions which are caused by certain central nervous
system (CNS) drugs such as fluphenazine, haloperidol,
chlorpromazine.