Peripheral blood (PB) film
in CLL showing two mature
lymphocytes and one smear cell.
Nuclear chromatin is condensed
and each cell contains a barely
detectable nucleolus. May–
Grünwald–Giemsa

PB film from a patient
with CLL showing: (a) a smear
cell and four lymphocytes
containing globular
immunoglobulin inclusions

immunocytochemistry showing
expression of immunoglobulin
M.

PB film from a patient with
CLL showing the negative image of
an immunoglobulin crystal.

PB film in CLL complicated
by autoimmune haemolytic
anaemia showing one mature
lymphocyte, one smear cell,
spherocytes and polychromatic
macrocytes

cll

cll

cll

cll

cll

cll

cll

CLL

CLL - BM

CLL/PLL

CLL/PLL

prolymphocytoid transformation of B-CLL.

prolymphocytoid transformation of B-CLL.

PB demonstrating many
prolymphocytes with prominent nucleolus

PB demonstrating prolymphocytes
with prominent nucleoli