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CLL
CLL - BM
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CLL/PLL
CLL/PLL
prolymphocytoid transformation of B-CLL.
prolymphocytoid transformation of B-CLL.
PB demonstrating many
prolymphocytes with prominent nucleolus
PB demonstrating prolymphocytes
with prominent nucleoli
BM with many prolymphocytes
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PB film in prolymphocytoid
transformation of CLL.
PB film in Richter
syndrome showing residual
mature small lymphocytes and
two large, immunoblast‐like
cells
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BM film in Richter
syndrome, same patient
PB film in B
prolymphocytic leukaemia (B‐PLL)
showing cells that are regular in
shape with round nuclei. Nuclear
chromatin shows some
condensation and the larger cells
contain prominent vesicular
nucl
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The prolymphocyte is a large cell
with often relatively abundant cytoplasm. The
nucleus is round with relatively well‐condensed
nuclear chromatin and with a prominent vesicular nucleolus showing perinucleolar chromatin
condensation. Occasionally the cytoplasm contains globules, Auer rod‐like crystals [184] or
azurophilic granules [185], which are composed
of immunoglobulin. One patient whose cells
showed erythrophagocytic activity has been
described [186].
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Evolution of B-CLL into diffuse
large B-cell lymphoma (Richter syndrome).
B-PLL
2025/09/17 03:16:05
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