P.F malaria positive Ring form.

Schistosoma. h (ova)

KOH Aspergillus spp

🔬Amastigoute of Leishmania parasite

🔬Amastigoute of Leishmania parasite

Gametocyte of P. F

Gametocyte of P. F

🔬schizont malaria

CLL - Small lymphocytes with smudge cells at
arrows

CLL -Albumin smear: same patient as
presented in

Addition of albumin to blood before smear
preparation stabilizes CLL cells, decreasing the
formation of smudge cells and allows for accurate
cell classification

CLL- Small lymphocytes with smudge cell

CLL-BM demonstrating many lymphocytes

CLL- MORPHOLOGY
Peripheral Blood: Mature-appearing lymphocytes with round nuclei and block-type chromatin; inconspicuous
nucleoli, scant cytoplasm; homogeneous appearance within a given patient; lymphocytes more fragile than
normal, leading to “smudge” cells
• Absolute sustained lymphocytosis
• Normocytic normochromic anemia (approximately 10% of patients develop an autoimmune hemolytic
anemia)
• Thrombocytopenia
Bone Marrow: 30% or more lymphocytes
IMMUNOPHENOTYPE
CD20+, CD19+, CD5+, CD23+

Peripheral blood (PB) film
in CLL showing two mature
lymphocytes and one smear cell.
Nuclear chromatin is condensed
and each cell contains a barely
detectable nucleolus. May–
Grünwald–Giemsa

PB film from a patient
with CLL showing: (a) a smear
cell and four lymphocytes
containing globular
immunoglobulin inclusions

immunocytochemistry showing
expression of immunoglobulin
M.

PB film from a patient with
CLL showing the negative image of
an immunoglobulin crystal.